Modeling Carbapenem Resistance Among Gram-Negative Pathogens Using Commonly Available Clinical Data

EMERGING WAVES OF CARBAPENEM RESISTANCE AMONG GRAM NEGATIVE PATHOGENS AT A TERTIARY CENTER by

Antimicrobial resistance among and therapeutic options against gram-negative pathogens.

Gram-negative bacterial pathogens are a common cause of infection, and the prevalence and rates of resistance among these pathogens to existing antimicrobial agents are increasing. beta-Lactamase-mediated resistance is of particular concern. High-level resistance attributable to beta-lactamase expression alone or in combination with other mechanisms is becoming increasingly prevalent among Ente...

Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has increased dramatically during the last 10 years, but the optimal treatment for CRGN infections is not well established due to the relative scarcity of robust clinical data. The polymyxins remain the most consistently active agents against CRGNs in vitro. Tigecycline, based on its in vitro antibacterial spectrum...

Antimicrobial Resistance among Gram-negative Bacilli

New Disturbing Trend in Antimicrobial Resistance of Gram-Negative Pathogens

1 Drug Resistance Proteomics Laboratory, Center for Antibiotic Resistance, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea, 2 Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Republic of Korea, 3 Structural Biology Laboratory, Marine Biotechnology Center, Korea Ocean Research and...